I too have been down this road and recently got rid of my 12-24 f4, 24-70 GM and 70-200GM. My kit today includes the 12-24 f2.8, 24-105 and the 100-400GM and the 200-600. The last lens I only take with me when wildlife is the primary objective. I have had primes in the past but find the quality of today's zooms quite good and the composition flexibility they offer makes them an obvious choice for me
I think my favorite lens is the 100-400GM. Much of my shooting is landscape and while I love ultra wide when foreground elimination is needed, I love the subject isolation long lenses offer.